Regular ArticleHippocampal Anatomy and Water Maze Performance Are Affected by Neonatal Cryoanesthesia in Rats of Both Sexes
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Cited by (28)
The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice
2014, Behavioural Brain ResearchCitation Excerpt :The reported effects of neonatal cryoanesthesia on the performance in water maze and brain morphology of adult Long-Evans rats [35,36,47] are interesting and should be investigated further in both species to elucidate possible differences between the species, the timing and duration of the procedure, and the possible modifications of the effects by environmental enrichments or socialization. The reported significant decreases in the volume of visual cortex [47], in the weight of hippocampus [35], as well as in cortical thickness and dendritic arborization [36] are likely not benign and will be reflected in compromised behavioral and specifically, cognitive propensities of the animals. These observed effects might be idiosyncratic for rats or even limited only to Long-Evans strain, or they can be the result of relatively impoverished housing conditions in animals facilities or unusually severe, non-biological hypothermia conditions employed in experimental studies.
Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress
2011, Hormones and BehaviorCitation Excerpt :It is possible that exposure to a surgical procedure (gonadectomy) two weeks prior to behavior testing and/or neonatal anesthesia may have affected anxiety-related behaviors in such a way as to eliminate differences between these groups. Neonatal anesthesia has previously been demonstrated to affect rat hippocampal morphology and cognitive behavior (Rothstein et al., 2008; Nuñez et al., 2000). Tfm males, like wt males, were also consistently less active than wt females as assessed by the number of rearings and grid crossings in the open field and novel object tests, consistent with reports of sex differences in motor activity (e.g., ambulation and rearing), with females more active (Archer, 1975; Masur et al., 1980; Slob et al., 1981; Seliger, 1977; Lucion et al., 1996).
Response to neonatal anesthesia: Effect of sex on anatomical and behavioral outcome
2008, NeuroscienceCitation Excerpt :The doses of phenobarbital and isoflurane were chosen based on previous reports of their efficacy as appropriate anesthetic agents in rats younger than PN3 (Yi and Barr, 1996; Bittigau et al., 2002). The duration of isoflurane exposure was chosen based on previous research by the experimenter on the average amount of time required to perform gonadectomies on rats on PN1 (Nuñez et al., 1998, 2000). This is significantly shorter than the 45–120 min time period of anesthesia documented by other laboratories required to perform surgeries in neonatal rodents (Park et al., 1992; Yi and Barr, 1996; Karuri et al., 1998) and human infants (Messmer et al., 1976; Oates et al., 1995).
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