SHORT COMMUNICATIONChromosome Localization of Human Genes for Clathrin Adaptor Polypeptides AP2β and AP50 and the Clathrin-Binding Protein, VCP
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APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD)
2007, Genetics in MedicineCitation Excerpt :There are many theoretical points of linkage, however. VCP is a clathrin-binding protein involved in endocytosis, Golgi processing, and membrane fusion, and is required for export of proteins from the endoplasmic reticulum to the cytosol.3,28-32 VCP has also been recently described as a targeting factor for specific proteins, e.g. nuclear factor kappa-B, to the ubiquitin proteosome pathway.33
Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca<sup>2+</sup> /calmodulin kinase II in rod outer segments
2006, Molecular and Cellular ProteomicsCitation Excerpt :Two proteins were down-regulated in rd1: β-adaptin and guanylate kinase. β-Adaptin is part of the AP2 coat assembly protein complex (55) involved in clathrin-mediated endocytosis of receptors (56, 57). In other tissues, β-adaptin combined with non-visual arrestins takes part in internalization of G protein-coupled receptors (GPCRs) (58) and thus contributes to GPCR desensitization and GPCR-induced signaling.
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2023, International MicrobiologyiTRAQ-Based Proteomic Reveals Cell Cycle and Translation Regulation Involving in Peanut Buds Cold Stress
2020, Russian Journal of Plant Physiology