Regular ArticleGenomic Structure of Human L-Type Ca2+ Channel
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Vascular Ca<inf>V</inf>1.2 channels in diabetes
2022, Current Topics in MembranesCitation Excerpt :CaV1.2 channels are subject to alternative splicing—a molecular biological transcriptional process that generates many variants from a single gene and may be involved in functional CaV1.2 diversity in health and disease (Hu, Liang, & Soong, 2017; Liao & Soong, 2010; Liao et al., 2007; Yang et al., 2000). The human gene for the CaV1.2 channel (cacna1c) has 50 exons, whereas the mouse and rat forms have 49 exons (Cheng et al., 2007; Liao, Yong, Liang, Yue, & Soong, 2005; Soldatov, 1994). At least 20 exons in the human cacna1c gene are possible sites for alternative splicing.
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