Regular articleIGF Enhancement of FGF-induced Fibre Differentiation and DNA Synthesis in Lens Explants
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MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation
2009, Experimental Eye ResearchCitation Excerpt :We know that other growth factors in the vitreous, including IGF, PDGF or EGF, can also activate the ERK1/2 pathway (Iyengar et al., 2006). IGF and PDGF can also potentiate FGF-induced lens fibre differentiation (Richardson et al., 1993; Liu et al., 1996; Kok et al., 2002). Future studies will be focussed on identifying which of these other growth factors, or combination of factors, is able to better reproduce the signalling (in particular Akt phosphorylation) induced by vitreous leading to fibre cell differentiation.
An essential role for FGF receptor signaling in lens development
2006, Seminars in Cell and Developmental BiologyExtracellular matrix and integrin signaling in lens development and cataract
2006, Seminars in Cell and Developmental BiologyAqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling
2006, Experimental Eye ResearchCitation Excerpt :In many cases, the addition of serum to maintain the viability of these cell lines may also alter the responses to specific growth factors, as some of these (e.g. FGF and EGF) have previously been reported to act synergistically with specific growth factors known to be present in serum (e.g. IGF, PDGF). Consequently, an enhanced mitotic (Reddan and Wilson-Dziedzic, 1983) or differentiation (Liu et al., 1996; Kok et al., 2002) response may be observed in serum-containing cultures. In the present study we have employed the rat lens epithelial explant system to compare the specific mitogenic effects of different growth factors with that of the AQ.
Octreotide inhibits growth factor-induced and basal proliferation of lens epithelial cells in vitro
2005, Journal of Cataract and Refractive SurgeryCitation Excerpt :Insulin-like growth factor and bFGF are among the most important growth factors associated with development and progression of cataract.18 Both factors have an essential role in epithelial cell proliferation, and they also influence differentiation of LECs to fiber cells.24 Both IGF-1 and bFGF are produced in the eye, especially in patients with proliferative diabetic retinopathy26–28 and tend to accumulate in the region of the posterior capsule.29
Growth factor regulation of lens development
2005, Developmental Biology
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For correspondence at: Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia 2006.