Regular ArticleTissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145: II. Expression in Situ in Lymphoid and Nonlymphoid Tissues
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Cellular and molecular targeting for nanotherapeutics in transplantation tolerance
2015, Clinical ImmunologyCitation Excerpt :Mahnke et al. showed that Ag complexed to anti-DEC-205 is presented 30–100 times more efficiently than anti-MR [57]. DEC-205 is expressed at high levels on DCs in lymphoid tissues, and antibodies toward DEC-205 have increased antigen uptake 400 times more than untargeted antigen [58,59]. Several models have demonstrated that PLG nanoparticles (NPs) encapsulating Ag displaying antibodies against the CLRs DEC-205 or DC immunoreceptor (DCIR) were taken up by DCs compared to non-targeted NPs both in vitro and in vivo [19,60].
Imbalance between CD205 and CD80/CD86 in dendritic cells in patients with immune thrombocytopenia
2015, Thrombosis ResearchCitation Excerpt :Thus, it was speculated that CD205 may be involved in the pathogenesis of ITP. CD205 is one of the least understood members of the macrophage mannose receptor family of C-type lectin receptors [3,4], which can capture endogenous glycoproteins and contribute to immune tolerance. It is an important tolerance-associated receptor that is mainly expressed in DCs and upregulated during DC maturation [5,6].