Biochemical and Biophysical Research Communications
Regular ArticleCloning and Characterization of the Human Stearoyl-CoA Desaturase Gene Promoter: Transcriptional Activation by Sterol Regulatory Element Binding Protein and Repression by Polyunsaturated Fatty Acids and Cholesterol☆
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2018, Journal of Dairy ScienceCitation Excerpt :This is in line with the current study, where we have shown that prolonged high-concentrate feeding induces secretion of insulin and subsequently elicits insulin resistance. This idea may be supported by the decreased gene expression of INSR and IRS1 in SARA cows, as the enzymes encoded by these genes play important roles in regulating multiple signaling pathways [i.e., phosphoinositide 3-kinase-serine/threonine kinase/mammalian target of rapamycin (PI3K-Akt/mTOR)] in response to insulin in the liver (Boucher et al., 2014). Moreover, we recently found an inhibition of hepatic mTOR signaling in grain-challenged cows (Xu et al., 2017), which has also been suggested to suppress lipid synthesis by inactivating SREBP1 (Düvel et al., 2010).
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Abbreviations used: SCD, stearoyl-CoA desaturase; SREBP, sterol regulatory element binding protein; PUFA, polyunsaturated fatty acid; AA, arachidonic acid; DHA, decosahexaenoic acid; EPA, ecosapentenoic acid; LA, linoleic acid.
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To whom correspondence should be addressed at Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706. Fax: 608-265-3272. E-mail: [email protected].