Biochemical and Biophysical Research Communications
Regular ArticleIdentification of an Orphan Receptor Gene as a Type 1 Calcitonin Gene-Related Peptide Receptor
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Atypical chemokine receptors in tumor cell growth and metastasis
2020, Advances in Cancer ResearchCitation Excerpt :Cloned from a canine cDNA library and identified as an orphan receptor (Libert, Parmentier, Lefort, Dumont, & Vassart, 1990), it was initially labeled as a receptor for vasoactive intestinal peptide-1 (VIP-1) and later disputed and alternatively termed as calcitonin-gene related peptide (CGRP) receptor. However, it was not until 2005 that the stromal-derived chemokine-1α, was identified as a ligand in human T-lymphocytes (Balabanian et al., 2005; Kapas & Clark, 1995; Nagata et al., 1992; Sreedharan, Robichon, Peterson, & Goetzl, 1991). As a receptor for SDF-1α, also known as CXC chemokine ligand-12 (CXCL12), RDC1/ACKR3 was relabeled as CXC-chemokine receptor 7 (CXCR7) and a year later Burns et al. reported CXCR7 binds to an iTAC-1 antigen, CXCL11, and was a co-receptor for CXCL12 along with CXCR4 (Balabanian et al., 2005; Burns et al., 2006).
Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development
2014, Developmental CellCitation Excerpt :Although our current study has focused on the effects of CXCR7 on AM-mediated cardiac and lymphatic development, it is important to recognize that the interaction of CXCR7 with AM may initiate downstream signaling and active processes in other cell types or tissues. For example, several studies have pointed to potential nondecoy functions of CXCR7, such as signaling through β-arrestin, heterodimerizing with other GPCRs in certain tissues, and coupling with G-proteins in astrocytes (Kapas and Clark, 1995; Odemis et al., 2012; Rajagopal et al., 2010). Therefore, while we have currently established CXCR7 as a molecular rheostat for AM signaling during cardiovascular development, future studies may identify potential CXCR7-GPCR complexes that allow for functional AM signaling in other cell types or tissues.
Decoys and cardiovascular development: CXCR7 and regulation of adrenomedullin signaling
2014, Developmental CellSequence-structure based phylogeny of GPCR Class A Rhodopsin receptors
2014, Molecular Phylogenetics and Evolution