Research ArticlesUse of Everted Intestinal Rings for in Vitro Examination of Oral Absorption Potential
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Nano lipid based carriers for lymphatic voyage of anti-cancer drugs: An insight into the in-vitro, ex-vivo, in-situ and in-vivo study models
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Now, this model has been extensively used for estimating the pharmacokinetics parameters related with drug absorption and metabolism [113,114]. Besides, it can provide an insight into the modulatory effect of lipid formulation excipients on efflux pumps [115]. [116] In a study conducted by Sha and Fang 2004, Caco-2 cell lines and everted gut sacs were utilized to investigate the transepithelial passage of 9-nitrocamptothecin (9-NC).
Models for drug absorption from the small intestine: where are we and where are we going?
2017, Drug Discovery TodayCitation Excerpt :However, one limiting parameter of this model is tissue viability [38]. Moreover, no in vivo correlation has been established through this method but results from everted intestinal sac models have been consistent with in vivo findings [39]. As for in vivo methods, the major drawback is the poor screening rate.
Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration
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2015, Concepts and Models for Drug Permeability Studies: Cell and Tissue based in Vitro Culture Models
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