Research ArticlesLinear Nonisothermal Stability Studies
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Application of iChemExplorer in pharmaceutical pH stress testing
2013, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :The use of the non-isothermal ICE protocol makes it possible to estimate the pH degradation activation energy Ea and other kinetic information using the same data generated during the non-isothermal part of the study. It has been demonstrated by many authors that a non-isothermal approach can be much more efficient in getting the activation energy with accuracy comparable to that from a conventional isothermal study [3,9–12]. The feasibility of using a non-isothermal ICE protocol to estimate the degradation activation energy and the associated accuracy were demonstrated previously using famotidine as a model compound [13].
A simulation study with statistical evaluation for the determination of non-isothermal kinetics conditions in drugs stability
2007, European Journal of Pharmaceutical SciencesBasics and applications of solid-state kinetics: A pharmaceutical perspective
2006, Journal of Pharmaceutical SciencesRapid ESI-MS method for examining the thermal decomposition of pharmaceuticals
2004, Journal of Pharmaceutical SciencesCitation Excerpt :Using this simple ESI–MS approach, an initial thermal degradation profile on a particular analyte as a function of the temperature of the inlet capillary can be established in a few hours versus days to weeks for more conventional accelerated aging measurements made using chromatographic, spectrometric, or electrochemical procedures. In the case of the ESI–MS approach, since most of the decomposition occurs in the gas phase as the analytes move through the heated capillary, the current investigation was carried out to examine how the resulting breakdown product(s) and elevated thermal stability of the analytes mimic that obtained by more conventional accelerated aging studies.5–11 The ACS reagent grade ammonium acetate and HPLC grade acetonitrile and methanol were purchased from Fisher Scientific (Pittsburgh, PA), and the acetaminophen, indomethacin, and mefenamic acid were obtained from Sigma (St. Louis, MO).
Automation of chemical reaction kinetics and product distribution studies in pharmaceutical development
2002, JALA - Journal of the Association for Laboratory Automation
Grateful acknowledgment is made to the National Research Council of Canada for financial assistance and to Dr. L. P. Chénier, Miss Joan Maxwell, and Mr. Leo Fleming of Frank W. Horner Ltd., Montreal, Quebec, Canada for performing the toxicity studies and testing some of the compounds for antiarrhythmic activity.