RESEARCH ARTICLE – Pharmaceutics, Drug Delivery and Pharmaceutical TechnologySemi-imprinting Quercetin into Poly[N,N-Dimethylacrylamide-co-3, 9-divinyl-2, 4, 8, 10-Tetraoxaspiro (5.5) Undecane] Network: Evaluation of the Antioxidant Character
Section snippets
INTRODUCTION
The interest in realizing compounds with antioxidant activities is entirely justified because antioxidants interacted with free radicals and stabilized them, thus preventing the free radicals from causing cell damage. In this context, poly[N,N-dimethylacrylamide-co-3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane] (PDMA-co-U) gel was prepared and quercetin was coupled through a semi-imprinted procedure into polymeric network to obtain a responsive antioxidant system.1., 2., 3.
The
Self-Assembled PDMA-co-U)/Quercetin Structure Preparation
First PDMA-co-U was synthesized through a process of copolymerization between PDMA-co-U monomers, found in a ratio of 70:30, and using benzoil peroxide as radical initiator and N, N-dimethylacetamide (DMAc) as solvent.1 Then, PDMA-co-U copolymer solution (of about 20% in DMAc) was cross-linked with N, N′-methylene bis-acrylamide (BisAAm in DMAc) (copolymer/cross-linker ratio of 10:1) using ammonium persulfate/N, N, N′, N′-tetramethylenediamine as redox system, at 25°C for 24 h, with or without
Evaluation of the Distribution of the Antioxidant Template into Polymeric Matrices
Near-infrared chemical imaging represents a perfect combination between near–infrared spectroscopy and image analysis. It provides information about the spatial distribution of the components comprising the sample and is used as fast and nondestructive alternative method for the quantification of excipients and active compounds within the polymeric matrices.18., 19., 20. The opportunity to visualize the spatial distribution of the bioactive substances (drugs) throughout the sample enables the
CONCLUSIONS
The study confirms the antioxidant properties of PDMA-co-U network with quercetin coupled through semi-imprinted procedure or quercetin loaded after polymer network preparation.
The evaluation of the antioxidant character of the new prepared complex was put into evidence by radical inhibitor activity method using DPPH. From the study, it was concluded about the possibility of coupling quercetin in interdependence with solicited antioxidant response: for a quickly antioxidant activity, quercetin
ACKNOWLEDGMENTS
This work was financially supported by the grant of the Romanian National Authority for Scientific Research, CNCS-UEFISCDI, project number PN-II-211/2012 “Interdisciplinary research on multifunctional hybrid particles for bio-requirements.”
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Possibilities of quercetin insertion into poly(N,N-dimethylacrylamide-co-3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane) network
2015, Materials Science and Engineering CCitation Excerpt :In the present study preparation and characterization of supramolecular structures based on PDMA-co-U and quercetin, obtained through a semi-imprinting procedure with or without the presence of a magnetic field during gelifying process, were investigated. The prepared composites were examined from the viewpoint of the antioxidant properties including in vivo evaluation, studies which constituting another presentation [25]. As it was previously presented, P(DMA-co-U) was synthesized by radical polymerization process between N,N-dimethylacrylamide and 3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane (U) (in a ratio of 70/30) and using benzoyl peroxide (PBO) as initiator and N,N-dimethylacetamide (DMAc) as solvent [1].
The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination
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