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Predicting Chemically Induced Skin Sensitization by Using In Chemico / In Vitro Methods

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Book cover Computational Toxicology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1800))

Abstract

Over the recent years development toward assessing skin sensitization hazard has moved toward non-animal testing methods. These methods are based on the key events as described in the OECD Adverse Outcome Pathway (AOP) for skin sensitization initiated by covalent binding to proteins. As these individual methods address mainly one mechanistic event (key event) in the initiation of skin sensitization, combination of different methods are needed to conclude on the skin sensitization hazard. Validated and regulatory adopted (EU and OECD) in chemico/in vitro methods are available for KEs 1–3 and are presented here. This chapter also illustrates how individual test methods can be combined by providing two examples of defined approaches to testing and assessment for skin sensitization hazard identification and assessment.

Laura H. Rossi is a staff member of the European Chemicals Agency; the views and opinions expressed in this article represent exclusively the personal ideas of the author and do not represent the official position of the Agency.

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Author information

Authors and Affiliations

  1. European Chemicals Agency (ECHA), Helsinki, Finland

    Laura H. Rossi

  2. National Institute for Public Health and the Environment (RIVM), Centre for Health Protection, Bitlhoven, The Netherlands

    Janine Ezendam

Authors
  1. Laura H. Rossi
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  2. Janine Ezendam
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Corresponding author

Correspondence to Laura H. Rossi .

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Editors and Affiliations

  1. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy

    Orazio Nicolotti

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Rossi, L.H., Ezendam, J. (2018). Predicting Chemically Induced Skin Sensitization by Using In Chemico / In Vitro Methods. In: Nicolotti, O. (eds) Computational Toxicology. Methods in Molecular Biology, vol 1800. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7899-1_22

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  • DOI: https://doi.org/10.1007/978-1-4939-7899-1_22

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